The CRISPR Era Is Here | The Pandemic Disrupted Adolescent Brain Development | 7 Rules for Job Interview Questions That Result in Great Hires | See The Luxury Homes CEOs And Founders Have Put On The Market This Year

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� � � � � � You Might Like � � � � � � � � � The CRISPR Era Is Here - The Atlantic    When Victoria Gray was still a baby, she started howling so inconsolably during a bath that she was rushed to the emergency room. The diagnosis was sickle-cell disease, a genetic condition that causes bouts of excruciating pain—“worse than a broken leg, worse than childbirth,” one doctor told me. Like lightning crackling in her body is how Gray, now 38, has described the pain. For most of her life, she lived in fear that it could strike at any moment, forcing her to drop everything to rush, once again, to the hospital. After a particularly long and debilitating hospitalization in college, Gray was so weak that she had to relearn how to stand, how to use a spoon. She dropped out of school. She gave up on her dream of becoming a nurse. Four years ago, she joined a groundbreaking clinical trial that would change her life. She became the first sickle-cell patient to be treated with the gene-editing technology CRISPR—and one of the first humans to be treated with CRISPR, period. CRISPR at that point had been hugely hyped, but had largely been used only to tinker with cells in a lab. When Gray got her experimental infusion, scientists did not know whether it would cure her disease or go terribly awry inside her. The therapy worked—better than anyone dared to hope. With her gene-edited cells, Gray now lives virtually symptom-free. Twenty-nine of 30 eligible patients in the trial went from multiple pain crises every year to zero in 12 months following treatment. Continued here � � � � � � You Might Like � � � � � � � � � The Pandemic Disrupted Adolescent Brain Development - Scientific American    Before COVID, American teenagers' psychological health was already in decline. The pandemic, with its sudden lockdowns, school closures and other jolts to normal life, made that downward slope steeper. The ensuing mental health crisis has given researchers a rare opportunity to gauge how an extraordinary event such as a public health catastrophe can physically affect the brains of teenagers. Preliminary results for some of these studies are starting to be reported—and they are sobering. At the annual Society for Neuroscience conference in Washington, D.C., this week, Elizabeth Powell, a program officer at the National Institutes of Health, characterized the situation as a definitive disruption in normal adolescent brain development. In one set of research results presented at the conference, Patricia Kuhl of the University of Washington reported a larger-than-normal thinning of the cerebral cortex in a group of 124 adolescents who had been tracked before the pandemic at ages nine to 17 and then again after the COVID lockdown period. "Our findings indicate that the teenage brain showed accelerated aging due to the pandemic lockdown," she said at the conference. Continued here � � � � � � You Might Like � � � � � � � � � Don't like ads? Go ad-free with TradeBriefs Premium 7 Rules for Job Interview Questions That Result in Great Hires - Harvard Business Review    Some of the long-held ideas about how to conduct interviews are no longer accurate. For example, there’s no such thing as a surprise interview question anymore. With sites like Glassdoor.com, candidates can identify each of your likely interview questions and expected answers ahead of time. With that information, candidates now routinely prepare and video their practice interviews to the point where their responses are universally impressive, if not genuine or accurate. Continued here � � � � � � You Might Like � � � � � � � � � See The Luxury Homes CEOs And Founders Have Put On The Market This Year - Forbes    From a ski chateau with a bowling ally to a sprawling horse ranch in Calabasas, the CEOs and founders of some of the nation’s biggest brands and most successful companies have taken the real estate market by storm this year, with several listings for ultra-luxury homes. Former Apple CEO Gil Amelio has listed the home at 5940 Lake Geneva Drive in Reno, Nevada for $9.4 ... [+] million. The billionaire founder of Rockstar energy drinks, Russ Weiner, currently has two Park City, Utah, homes on the market, including a $50 million, ski-in/ski-out compound named "Monitor's Rest” that includes almost 18,000 square feet of living space, a 60-foot indoor/outdoor pool, wellness spa, gym, Himalayan salt room, indoor sports court, golf simulator, bowling alley and media room equipped with a 200-inch laser projection system. Continued here

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