KRAS, the ideal cancer drug target that became ‘undruggable,’ takes on a new glow | In Japan, the young find dating so hard their parents are doing it for them | CNN | Japan driving school lets people try drink driving to experience its dangers first-hand

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You Might Like � � � You Might Like � � � � � � � � � Don't like ads? Go ad-free with TradeBriefs Premium KRAS, the ideal cancer drug target that became 'undruggable,' takes on a new glow - STAT    On Target is a recurring feature from STAT that dives deep into the most promising drug targets in oncology. KRAS, one of the most common genetic mutations in cancer, has been one of the most tantalizing oncogenic targets for drug developers since its discovery four decades ago. An altered KRAS gene can drive cells to divide uncontrollably, propelling them down the path towards malignancy. But for most of the last four decades, any attempt to target KRAS failed, leading many researchers to doom the protein as “undruggable.” In the last few years, that attitude has sharply turned around. In 2013, Kevan Shokat, a biologist at the University of California, San Francisco, discovered a key chemical vulnerability in a specific subset of mutant oncogenic KRAS that made it possible to design small molecules that would bind to the protein. This discovery catalyzed a frenzy of drug development around KRAS inhibitors, which eventually led to the first approved KRAS drugs in the last couple of years. Those successes are now driving a new wave of early-stage innovation around the target. Continued here In Japan, the young find dating so hard their parents are doing it for them | CNN - CNN    It's a steamy summer afternoon in the Japanese city of Osaka, where a group of around 60 men and women have gathered for a session of "omiai," or matchmaking, to find true love. They mingle away, hopping from one end of the conference room at the Sakai Chamber of Commerce building to another as they assess potential matches - and the competition. Few of the participants are talking about their favorite hobbies, movies or restaurants, or indeed, even about themselves. They are talking about their grown-up, still single children who they are hoping to match up and marry off. Continued here Japan driving school lets people try drink driving to experience its dangers first-hand -     To highlight the dangers of drink driving, a driving school in Japan adopted an experiential approach — letting participants try driving while drunk to find out for themselves. School instructors let participants complete a test circuit when sober, and try it again once they were suitably intoxicated. The experiment was held at Chikushino Driving School in Fukuoka, Japan, on Aug. 21, reported Mainichi Shinbun, a Japan-based newspaper. Continued here

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